Target of rapamycin complex subunit LST8 (MLST8)

About Target of rapamycin complex subunit LST8

Target of rapamycin complex subunit LST8 (MLST8) is a protein from Homo sapiens identified by UniProt accession Q9BVC4, 326 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	Target of rapamycin complex subunit LST8
UniProt accession	Q9BVC4
Gene	MLST8
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
glioblastoma multiforme · score 0.30
ovarian cancer · score 0.29
lung adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.27
urinary bladder cancer · score 0.20
body height · score 0.19
appendicular lean mass · score 0.18
sitting height measurement · score 0.14
neoplasm · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVC4-F1	alphafold	PREDICTED	91.64	—

Amino-acid sequence (326 residues)

MNTSPGTVGS DPVILATAGY DHTVRFWQAH SGICTRTVQH QDSQVNALEV TPDRSMIAAA GYQHIRMYDL NSNNPNPIIS YDGVNKNIAS VGFHEDGRWM YTGGEDCTAR IWDLRSRNLQ CQRIFQVNAP INCVCLHPNQ AELIVGDQSG AIHIWDLKTD HNEQLIPEPE VSITSAHIDP DASYMAAVNS TGNCYVWNLT GGIGDEVTQL IPKTKIPAHT RYALQCRFSP DSTLLATCSA DQTCKIWRTS NFSLMTELSI KSGNPGESSR GWMWGCAFSG DSQYIVTASS DNLARLWCVE TGEIKREYGG HQKAVVCLAF NDSVLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards