tRNA-splicing ligase complex subunit ASW (C2orf49)

About tRNA-splicing ligase complex subunit ASW

tRNA-splicing ligase complex subunit ASW (C2orf49) is a protein from Homo sapiens identified by UniProt accession Q9BVC5, 232 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	tRNA-splicing ligase complex subunit ASW
UniProt accession	Q9BVC5
Gene	C2orf49
Organism	Homo sapiens
Length	232 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
lysosomal storage disease · score 0.37
body mass index · score 0.30
self reported educational attainment · score 0.27
smoking status measurement · score 0.24
body fat percentage · score 0.23
smoking behaviour measurement · score 0.20
tobacco smoke exposure measurement · score 0.19
antisocial behaviour measurement · score 0.19
attention deficit hyperactivity disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVC5-F1	alphafold	PREDICTED	65.32	—

Amino-acid sequence (232 residues)

MAGDVGGRSC TDSELLLHPE LLSQEFLLLT LEQKNIAVET DVRVNKDSLT DLYVQHAIPL PQRDLPKNRW GKMMEKKREQ HEIKNETKRS STVDGLRKRP LIVFDGSSTS TSIKVKKTEN GDNDRLKPPP QASFTSNAFR KLSNSSSSVS PLILSSNLPV NNKTEHNNND AKQNHDLTHR KSPSGPVKSP PLSPVGTTPV KLKRAAPKEE AEAMNNLKPP QAKRKIQHVT WP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards