About Voltage-gated monoatomic cation channel TMEM109
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) is a protein
from Homo sapiens identified by UniProt accession
Q9BVC6, 243 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Voltage-gated monoatomic cation channel TMEM109 |
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| UniProt accession | Q9BVC6 |
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| Gene | TMEM109 |
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| Organism | Homo sapiens |
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| Length | 243 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- blood protein measurement · score 0.10
- left ventricular hypertrophy · score 0.01
- bacteriemia · score 0.01
- septic shock · score 0.01
- lung adenocarcinoma · score 0.01
- multiple myeloma · score 0.00
- cancer · score 0.00
- bladder transitional cell carcinoma · score 0.00
- astrocytoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BVC6-F1 | alphafold | PREDICTED | 67.45 | — |
Amino-acid sequence (243 residues)
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE
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