About Phosphatidylserine synthase 2
Phosphatidylserine synthase 2 (PTDSS2) is a protein
from Homo sapiens identified by UniProt accession
Q9BVG9, 487 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Phosphatidylserine synthase 2 |
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| UniProt accession | Q9BVG9 |
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| Gene | PTDSS2 |
|---|
| Organism | Homo sapiens |
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| Length | 487 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (146)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- Immature Reticulocyte Fraction Measurement · score 0.13
- HbA1c measurement · score 0.09
- reticulocyte measurement · score 0.08
- azoospermia · score 0.08
- primary ovarian insufficiency · score 0.07
- reticulocyte count · score 0.07
- 46,XX gonadal dysgenesis · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.07
- Testicular regression syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BVG9-F1 | alphafold | PREDICTED | 81.89 | — |
Amino-acid sequence (487 residues)
MRRGERRDAG GPRPESPVPA GRASLEEPPD GPSAGQATGP GEGRRSTESE VYDDGTNTFF WRAHTLTVLF ILTCTLGYVT LLEETPQDTA YNTKRGIVAS ILVFLCFGVT QAKDGPFSRP HPAYWRFWLC VSVVYELFLI FILFQTVQDG RQFLKYVDPK LGVPLPERDY GGNCLIYDPD NETDPFHNIW DKLDGFVPAH FLGWYLKTLM IRDWWMCMII SVMFEFLEYS LEHQLPNFSE CWWDHWIMDV LVCNGLGIYC GMKTLEWLSL KTYKWQGLWN IPTYKGKMKR IAFQFTPYSW VRFEWKPASS LRRWLAVCGI ILVFLLAELN TFYLKFVLWM PPEHYLVLLR LVFFVNVGGV AMREIYDFMD DPKPHKKLGP QAWLVAAITA TELLIVVKYD PHTLTLSLPF YISQCWTLGS VLALTWTVWR FFLRDITLRY KETRWQKWQN KDDQGSTVGN GDQHPLGLDE DLLGPGVAEG EGAPTPN
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