Nucleolar complex protein 4 homolog (NOC4L)

About Nucleolar complex protein 4 homolog

Nucleolar complex protein 4 homolog (NOC4L) is a protein from Homo sapiens identified by UniProt accession Q9BVI4, 516 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Nucleolar complex protein 4 homolog
UniProt accession	Q9BVI4
Gene	NOC4L
Organism	Homo sapiens
Length	516 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

lysosomal storage disease · score 0.46
Alzheimer disease · score 0.46
neurodegenerative disease · score 0.46
Parkinson disease · score 0.46
multiple sclerosis · score 0.46
mean corpuscular volume · score 0.21
alcohol drinking · score 0.15
body height · score 0.14
lean body mass · score 0.13
sitting height measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVI4-F1	alphafold	PREDICTED	89.42	—

Amino-acid sequence (516 residues)

MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV RTCSRLFGAL LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC NRLGELLGHP SFQVKELALS ALLKFVQLEG AHPLEKSKWE GNYLFPRELF KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT RYHTMQAAVD AVARVTGQHP EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW KVAHLKEHRR VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL ADLFLSSSHL PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA CRVLVHRPHG PELDADPYDP GEEDPAQSRA LESSLWELQA LQRHYHPEVS KAASVINQAL SMPEVSIAPL LELTAYEIFE RDLKKKGPEP VPLEFIPAQG LLGRPGELCA QHFTLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards