Gamma-glutamylaminecyclotransferase (GGACT)

About Gamma-glutamylaminecyclotransferase

Gamma-glutamylaminecyclotransferase (GGACT) is a protein from Homo sapiens identified by UniProt accession Q9BVM4, 153 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Gamma-glutamylaminecyclotransferase
UniProt accession	Q9BVM4
Gene	GGACT
Organism	Homo sapiens
Length	153 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

body height · score 0.43
smoking status measurement · score 0.43
age at onset · score 0.39
Myopia · score 0.39
smoking behavior · score 0.37
refractive error · score 0.34
smoking initiation · score 0.32
attention deficit hyperactivity disorder · score 0.31
antisocial behaviour measurement · score 0.31
substance abuse · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVM4-F1	alphafold	PREDICTED	92.11	—

Amino-acid sequence (153 residues)

MALVFVYGTL KRGQPNHRVL RDGAHGSAAF RARGRTLEPY PLVIAGEHNI PWLLHLPGSG RLVEGEVYAV DERMLRFLDD FESCPALYQR TVLRVQLLED RAPGAEEPPA PTAVQCFVYS RATFPPEWAQ LPHHDSYDSE GPHGLRYNPR ENR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards