About ATPase family gene 2 protein homolog B
ATPase family gene 2 protein homolog B (AFG2B) is a protein
from Homo sapiens identified by UniProt accession
Q9BVQ7, 753 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | ATPase family gene 2 protein homolog B |
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| UniProt accession | Q9BVQ7 |
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| Gene | AFG2B |
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| Organism | Homo sapiens |
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| Length | 753 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- hearing loss, autosomal recessive 119 · score 0.59
- hearing loss, autosomal recessive · score 0.37
- genetic disorder · score 0.34
- Neurodevelopmental delay · score 0.33
- creatinine measurement · score 0.27
- glomerular filtration rate · score 0.21
- serum metabolite measurement · score 0.19
- chronic kidney disease · score 0.12
- urinary albumin to creatinine ratio · score 0.12
- blood protein measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BVQ7-F1 | alphafold | PREDICTED | 77.10 | — |
Amino-acid sequence (753 residues)
MAPDSDPFPE GPLLKLLPLD ARDRGTQRCR LGPAALHALG ARLGSAVKIS LPDGGSCLCT AWPRRDGADG FVQLDPLCAS PGAAVGASRS RRSLSLNRLL LVPCPPLRRV AVWPVLRERA GAPGARNTAA VLEAAQELLR NRPISLGHVV VAPPGAPGLV AALHIVGGTP SPDPAGLVTP RTRVSLGGEP PSEAQPQPEV PLGGLSEAAD SLRELLRLPL RYPRALTALG LAVPRGVLLA GPPGVGKTQL VRAVAREAGA ELLAVSAPAL QGSRPGETEE NVRRVFQRAR ELASRGPSLL FLDEMDALCP QRGSRAPESR VVAQVLTLLD GASGDREVVV VGATNRPDAL DPALRRPGRF DREVVIGTPT LKQRKEILQV ITSKMPISSH VDLGLLAEMT VGYVGADLTA LCREAAMHAL LHSEKNQDNP VIDEIDFLEA FKNIQPSSFR SVIGLMDIKP VDWEEIGGLE DVKLKLKQSI EWPLKFPWEF VRMGLTQPKG VLLYGPPGCA KTTLVRALAT SCHCSFVSVS GADLFSPFVG DSEKVLSQIF RQARASTPAI LFLDEIDSIL GARSASKTGC DVQERVLSVL LNELDGVGLK TIERRGSKSS QQEFQEVFNR SVMIIAATNR PDVLDTALLR PGRLDKIIYI PPPDHKGRLS ILKVCTKTMP IGPDVSLENL AAETCFFSGA DLRNLCTEAA LLALQENGLD ATTVKQEHFL KSLKTVKPSL SCKDLALYEN LFKKEGFSNV EGI
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