About Serine/threonine-protein kinase RIO2
Serine/threonine-protein kinase RIO2 (RIOK2) is a protein
from Homo sapiens identified by UniProt accession
Q9BVS4, 552 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase RIO2 |
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| UniProt accession | Q9BVS4 |
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| Gene | RIOK2 |
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| Organism | Homo sapiens |
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| Length | 552 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Alzheimer disease · score 0.52
- Parkinson disease · score 0.52
- multiple sclerosis · score 0.52
- lysosomal storage disease · score 0.52
- neuroinflammatory disorder · score 0.42
- sleep duration · score 0.15
- triglyceride measurement · score 0.15
- neoplasm · score 0.09
- cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BVS4-F1 | alphafold | PREDICTED | 67.36 | — |
Amino-acid sequence (552 residues)
MGKVNVAKLR YMSRDDFRVL TAVEMGMKNH EIVPGSLIAS IASLKHGGCN KVLRELVKHK LIAWERTKTV QGYRLTNAGY DYLALKTLSS RQVVESVGNQ MGVGKESDIY IVANEEGQQF ALKLHRLGRT SFRNLKNKRD YHKHRHNVSW LYLSRLSAMK EFAYMKALYE RKFPVPKPID YNRHAVVMEL INGYPLCQIH HVEDPASVYD EAMELIVKLA NHGLIHGDFN EFNLILDESD HITMIDFPQM VSTSHPNAEW YFDRDVKCIK DFFMKRFSYE SELFPTFKDI RREDTLDVEV SASGYTKEMQ ADDELLHPLG PDDKNIETKE GSEFSFSDGE VAEKAEVYGS ENESERNCLE ESEGCYCRSS GDPEQIKEDS LSEESADARS FEMTEFNQAL EEIKGQVVEN NSVTEFSEEK NRTENYNRQD GQRVQGGVPA GSDEYEDECP HLIALSSLNR EFRPFRDEEN VGAMNQYRTR TLSITSSGSA VSCSTIPPEL VKQKVKRQLT KQQKSAVRRR LQKGEANIFT KQRRENMQNI KSSLEAASFW GE
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