About tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (TRMT61B) is a protein
from Homo sapiens identified by UniProt accession
Q9BVS5, 477 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial |
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| UniProt accession | Q9BVS5 |
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| Gene | TRMT61B |
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| Organism | Homo sapiens |
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| Length | 477 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- lysosomal storage disease · score 0.26
- multiple sclerosis · score 0.26
- Parkinson disease · score 0.26
- Alzheimer disease · score 0.26
- erythrocyte count · score 0.25
- hemoglobin measurement · score 0.23
- intraocular pressure measurement · score 0.18
- self reported educational attainment · score 0.17
- hematocrit · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BVS5-F1 | alphafold | PREDICTED | 71.62 | — |
Amino-acid sequence (477 residues)
MLMAWCRGPV LLCLRQGLGT NSFLHGLGQE PFEGARSLCC RSSPRDLRDG EREHEAAQRK APGAESCPSL PLSISDIGTG CLSSLENLRL PTLREESSPR ELEDSSGDQG RCGPTHQGSE DPSMLSQAQS ATEVEERHVS PSCSTSRERP FQAGELILAE TGEGETKFKK LFRLNNFGLL NSNWGAVPFG KIVGKFPGQI LRSSFGKQYM LRRPALEDYV VLMKRGTAIT FPKDINMILS MMDINPGDTV LEAGSGSGGM SLFLSKAVGS QGRVISFEVR KDHHDLAKKN YKHWRDSWKL SHVEEWPDNV DFIHKDISGA TEDIKSLTFD AVALDMLNPH VTLPVFYPHL KHGGVCAVYV VNITQVIELL DGIRTCELAL SCEKISEVIV RDWLVCLAKQ KNGILAQKVE SKINTDVQLD SQEKIGVKGE LFQEDDHEES HSDFPYGSFP YVARPVHWQP GHTAFLVKLR KVKPQLN
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