Transmembrane and ubiquitin-like domain-containing…

About Transmembrane and ubiquitin-like domain-containing protein 1

Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) is a protein from Homo sapiens identified by UniProt accession Q9BVT8, 246 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Transmembrane and ubiquitin-like domain-containing protein 1
UniProt accession	Q9BVT8
Gene	TMUB1
Organism	Homo sapiens
Length	246 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.09
functional brain measurement · score 0.09
neoplasm · score 0.09
creatinine measurement · score 0.06
cortical thickness · score 0.04
cancer · score 0.04
cortical surface area measurement · score 0.03
lean body mass · score 0.03
attention deficit hyperactivity disorder · score 0.03
body mass index · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVT8-F1	alphafold	PREDICTED	65.88	—

Amino-acid sequence (246 residues)

MTLIEGVGDE VTVLFSVLAC LLVLALAWVS THTAEGGDPL PQPSGTPTPS QPSAAMAATD SMRGEAPGAE TPSLRHRGQA AQPEPSTGFT ATPPAPDSPQ EPLVLRLKFL NDSEQVARAW PHDTIGSLKR TQFPGREQQV RLIYQGQLLG DDTQTLGSLH LPPNCVLHCH VSTRVGPPNP PCPPGSEPGP SGLEIGSLLL PLLLLLLLLL WYCQIQYRPF FPLTATLGLA GFTLLLSLLA FAMYRP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)