Small integral membrane protein 2 (SMIM2)

About Small integral membrane protein 2

Small integral membrane protein 2 (SMIM2) is a protein from Homo sapiens identified by UniProt accession Q9BVW6, 85 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Small integral membrane protein 2
UniProt accession	Q9BVW6
Gene	SMIM2
Organism	Homo sapiens
Length	85 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.42
waist-hip ratio · score 0.40
FEV/FVC ratio · score 0.38
facial asymmetry measurement · score 0.33
schizophrenia · score 0.32
PHF-tau measurement · score 0.31
heel bone mineral density · score 0.28
protein measurement · score 0.27
hair colour measurement · score 0.26
smoking behavior · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BVW6-F1	alphafold	PREDICTED	66.32	—

Amino-acid sequence (85 residues)

MEAGERIDAS QLPHRVLETR GHAISILFGF WTSFICDTYI VLAWISKIKG SPDVSASSDE PYARIQQSRR QCHAEEDQSQ VPEAG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards