About Transmembrane protein 106C
Transmembrane protein 106C (TMEM106C) is a protein
from Homo sapiens identified by UniProt accession
Q9BVX2, 250 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Transmembrane protein 106C |
|---|
| UniProt accession | Q9BVX2 |
|---|
| Gene | TMEM106C |
|---|
| Organism | Homo sapiens |
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| Length | 250 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- lymphocyte percentage of leukocytes · score 0.20
- neutrophil percentage of leukocytes · score 0.19
- forced expiratory volume · score 0.14
- peak expiratory flow · score 0.11
- body height · score 0.10
- hepatocellular carcinoma · score 0.10
- appendicular lean mass · score 0.05
- heel bone mineral density · score 0.04
- grip strength measurement · score 0.04
- lymphocyte count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BVX2-F1 | alphafold | PREDICTED | 80.79 | — |
Amino-acid sequence (250 residues)
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI
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