Very long chain fatty acid elongase 1 (ELOVL1)

About Very long chain fatty acid elongase 1

Very long chain fatty acid elongase 1 (ELOVL1) is a protein from Homo sapiens identified by UniProt accession Q9BW60, 279 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Very long chain fatty acid elongase 1
UniProt accession	Q9BW60
Gene	ELOVL1
Organism	Homo sapiens
Length	279 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

ichthyotic keratoderma, spasticity, hypomyelination, and dysmorphic facial features · score 0.66
neurodegenerative disease · score 0.29
systolic blood pressure · score 0.13
hepatocellular carcinoma · score 0.08
diastolic blood pressure · score 0.07
neoplasm · score 0.06
platelet count · score 0.06
IGF-1 measurement · score 0.05
white matter microstructure measurement · score 0.05
hemoglobin measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BW60-F1	alphafold	PREDICTED	89.90	—

Amino-acid sequence (279 residues)

MEAVVNLYQE VMKHADPRIQ GYPLMGSPLL MTSILLTYVY FVLSLGPRIM ANRKPFQLRG FMIVYNFSLV ALSLYIVYEF LMSGWLSTYT WRCDPVDYSN SPEALRMVRV AWLFLFSKFI ELMDTVIFIL RKKDGQVTFL HVFHHSVLPW SWWWGVKIAP GGMGSFHAMI NSSVHVIMYL YYGLSAFGPV AQPYLWWKKH MTAIQLIQFV LVSLHISQYY FMSSCNYQYP VIIHLIWMYG TIFFMLFSNF WYHSYTKGKR LPRALQQNGA PGIAKVKAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards