HIG1 domain family member 2A, mitochondrial (HIGD2A)

About HIG1 domain family member 2A, mitochondrial

HIG1 domain family member 2A, mitochondrial (HIGD2A) is a protein from Homo sapiens identified by UniProt accession Q9BW72, 106 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	HIG1 domain family member 2A, mitochondrial
UniProt accession	Q9BW72
Gene	HIGD2A
Organism	Homo sapiens
Length	106 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.13
hepatocellular carcinoma · score 0.08
cancer · score 0.07
neoplasm · score 0.07
gut microbiome measurement · score 0.06
diffuse large B-cell lymphoma · score 0.04
dilated cardiomyopathy 1I · score 0.03
lung adenocarcinoma · score 0.01
Invasive Breast Carcinoma · score 0.01
prostate adenocarcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BW72-F1	alphafold	PREDICTED	63.05	—

Amino-acid sequence (106 residues)

MATPGPVIPE VPFEPSKPPV IEGLSPTVYR NPESFKEKFV RKTRENPVVP IGCLATAAAL TYGLYSFHRG NSQRSQLMMR TRIAAQGFTV AAILLGLAVT AMKSRP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards