About Intraflagellar transport protein 27 homolog
Intraflagellar transport protein 27 homolog (IFT27) is a protein
from Homo sapiens identified by UniProt accession
Q9BW83, 186 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 27 homolog |
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| UniProt accession | Q9BW83 |
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| Gene | IFT27 |
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| Organism | Homo sapiens |
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| Length | 186 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (108)
Diseases linked to this target (Open Targets).
- Bardet-Biedl syndrome · score 0.66
- Polydactyly · score 0.37
- polydactyly · score 0.37
- genetic disorder · score 0.18
- Robinow syndrome · score 0.04
- familial thoracic aortic aneurysm and aortic dissection · score 0.04
- Loeys-Dietz syndrome · score 0.04
- Heterotaxia · score 0.04
- visceral heterotaxy · score 0.04
- Orofaciodigital syndrome type 2 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BW83-F1 | alphafold | PREDICTED | 92.70 | — |
Amino-acid sequence (186 residues)
MVKLAAKCIL AGDPAVGKTA LAQIFRSDGA HFQKSYTLTT GMDLVVKTVP VPDTGDSVEL FIFDSAGKEL FSEMLDKLWE SPNVLCLVYD VTNEESFNNC SKWLEKARSQ APGISLPGVL VGNKTDLAGR RAVDSAEARA WALGQGLECF ETSVKEMENF EAPFHCLAKQ FHQLYREKVE VFRALA
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