Splicing factor YJU2 (YJU2)

About Splicing factor YJU2

Splicing factor YJU2 (YJU2) is a protein from Homo sapiens identified by UniProt accession Q9BW85, 323 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Splicing factor YJU2
UniProt accession	Q9BW85
Gene	YJU2
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.29
interleukin-27 measurement · score 0.29
protein measurement · score 0.18
essential tremor · score 0.07
age-related macular degeneration · score 0.07
X-linked retinal dysplasia · score 0.06
Young adult-onset Parkinsonism · score 0.06
Familial exudative vitreoretinopathy · score 0.06
Hereditary late-onset Parkinson disease · score 0.06
optic atrophy 2 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BW85-F1	alphafold	PREDICTED	73.04	—

Amino-acid sequence (323 residues)

MSERKVLNKY YPPDFDPSKI PKLKLPKDRQ YVVRLMAPFN MRCKTCGEYI YKGKKFNARK ETVQNEVYLG LPIFRFYIKC TRCLAEITFK TDPENTDYTM EHGATRNFQA EKLLEEEEKR VQKEREDEEL NNPMKVLENR TKDSKLEMEV LENLQELKDL NQRQAHVDFE AMLRQHRLSE EERRRQQQEE DEQETAALLE EARKRRLLED SDSEDEAAPS PLQPALRPNP TAILDEAPKP KRKVEVWEQS VGSLGSRPPL SRLVVVKKAK ADPDCSNGQP QAAPTPGAPQ NRKEANPTPL TPGASSLSQL GAYLDSDDSN GSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards