ADP-ribose pyrophosphatase (NUDT9)

About ADP-ribose pyrophosphatase

ADP-ribose pyrophosphatase (NUDT9) is a protein from Homo sapiens identified by UniProt accession Q9BW91, 350 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	ADP-ribose pyrophosphatase
UniProt accession	Q9BW91
Gene	NUDT9
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.33
intelligence · score 0.23
mean corpuscular volume · score 0.02
sex hormone-binding globulin measurement · score 0.02
urate measurement · score 0.02
heel bone mineral density · score 0.02
gout · score 0.02
cancer · score 0.01
small cell lung carcinoma · score 0.01
Alzheimer disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BW91-F1	alphafold	PREDICTED	84.61	—

Amino-acid sequence (350 residues)

MAGRLLGKAL AAVSLSLALA SVTIRSSRCR GIQAFRNSFS SSWFHLNTNV MSGSNGSKEN SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT AVSVLAGPRW ADPQISESNF SPKFNEKDGH VERKSKNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA ADPIITRWKR DSSGNKIMHP VSGKHILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ KTSAEKREIE EKLHKLFSQD HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGEIMDNLML EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards