About Threonine--tRNA ligase, mitochondrial
Threonine--tRNA ligase, mitochondrial (TARS2) is a protein
from Homo sapiens identified by UniProt accession
Q9BW92, 718 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Threonine--tRNA ligase, mitochondrial |
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| UniProt accession | Q9BW92 |
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| Gene | TARS2 |
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| Organism | Homo sapiens |
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| Length | 718 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (87)
Diseases linked to this target (Open Targets).
- Combined oxidative phosphorylation defect type 21 · score 0.72
- neurodegenerative disease · score 0.56
- mitochondrial oxidative phosphorylation disorder · score 0.53
- Parkinson disease · score 0.50
- Alzheimer disease · score 0.50
- multiple sclerosis · score 0.50
- lysosomal storage disease · score 0.50
- neuroinflammatory disorder · score 0.46
- genetic disorder · score 0.19
- Neurodevelopmental disorder · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BW92-F1 | alphafold | PREDICTED | 91.04 | — |
Amino-acid sequence (718 residues)
MALYQRWRCL RLQGLQACRL HTAVVSTPPR WLAERLGLFE ELWAAQVKRL ASMAQKEPRT IKISLPGGQK IDAVAWNTTP YQLARQISST LADTAVAAQV NGEPYDLERP LETDSDLRFL TFDSPEGKAV FWHSSTHVLG AAAEQFLGAV LCRGPSTEYG FYHDFFLGKE RTIRGSELPV LERICQELTA AARPFRRLEA SRDQLRQLFK DNPFKLHLIE EKVTGPTATV YGCGTLVDLC QGPHLRHTGQ IGGLKLLSNS SSLWRSSGAP ETLQRVSGIS FPTTELLRVW EAWREEAELR DHRRIGKEQE LFFFHELSPG SCFFLPRGTR VYNALVAFIR AEYAHRGFSE VKTPTLFSTK LWEQSGHWEH YQEDMFAVQP PGSDRPPSSQ SDDSTRHITD TLALKPMNCP AHCLMFAHRP RSWRELPLRL ADFGALHRAE ASGGLGGLTR LRCFQQDDAH IFCTTDQLEA EIQSCLDFLR SVYAVLGFSF RLALSTRPSG FLGDPCLWDQ AEQVLKQALK EFGEPWDLNS GDGAFYGPKI DVHLHDALGR PHQCGTIQLD FQLPLRFDLQ YKGQAGALER PVLIHRAVLG SVERLLGVLA ESCGGKWPLW LSPFQVVVIP VGSEQEEYAK EAQQSLRAAG LVSDLDADSG LTLSRRIRRA QLAHYNFQFV VGQKEQSKRT VNIRTRDNRR LGEWDLPEAV QRLVELQNTR VPNAEEIF
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