Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

About Acetyl-CoA acetyltransferase, cytosolic

Acetyl-CoA acetyltransferase, cytosolic (ACAT2) is a protein from Homo sapiens identified by UniProt accession Q9BWD1, 397 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Acetyl-CoA acetyltransferase, cytosolic
UniProt accession	Q9BWD1
Gene	ACAT2
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
prostate carcinoma · score 0.14
acetyl-CoA acetyltransferase-2 deficiency · score 0.12
lipoprotein A measurement · score 0.05
QRS complex · score 0.05
electrocardiography · score 0.05
QRS duration · score 0.05
polycystic ovary syndrome · score 0.05
adolescent idiopathic scoliosis · score 0.05
low density lipoprotein cholesterol measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BWD1-F1	alphafold	PREDICTED	97.21	—

Amino-acid sequence (397 residues)

MNAGSDPVVI VSAARTIIGS FNGALAAVPV QDLGSTVIKE VLKRATVAPE DVSEVIFGHV LAAGCGQNPV RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAVQSIGIGD SSIVVAGGME NMSKAPHLAY LRTGVKIGEM PLTDSILCDG LTDAFHNCHM GITAENVAKK WQVSREDQDK VAVLSQNRTE NAQKAGHFDK EIVPVLVSTR KGLIEVKTDE FPRHGSNIEA MSKLKPYFLT DGTGTVTPAN ASGINDGAAA VVLMKKSEAD KRGLTPLARI VSWSQVGVEP SIMGIGPIPA IKQAVTKAGW SLEDVDIFEI NEAFAAVSAA IVKELGLNPE KVNIEGGAIA LGHPLGASGC RILVTLLHTL ERMGRSRGVA ALCIGGGMGI AMCVQRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards