E3 ubiquitin-protein ligase TRAIP (TRAIP)

About E3 ubiquitin-protein ligase TRAIP

E3 ubiquitin-protein ligase TRAIP (TRAIP) is a protein from Homo sapiens identified by UniProt accession Q9BWF2, 469 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRAIP
UniProt accession	Q9BWF2
Gene	TRAIP
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

Seckel syndrome · score 0.68
neurodegenerative disease · score 0.54
isolated growth hormone deficiency type IA · score 0.46
microcephalic primordial dwarfism · score 0.37
genetic disorder · score 0.19
erythrocyte count · score 0.15
diastolic blood pressure · score 0.12
cognitive function measurement · score 0.11
C-reactive protein measurement · score 0.10
bone quantitative ultrasound measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BWF2-F1	alphafold	PREDICTED	74.93	—

Amino-acid sequence (469 residues)

MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKRTIIN KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS QVIIDTLRDT LEERNATVVS LQQALGKAEM LCSTLKKQMK YLEQQQDETK QAQEEARRLR SKMKTMEQIE LLLQSQRPEV EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKASGE VADKLRKDLF SSRSKLQTVY SELDQAKLEL KSAQKDLQSA DKEIMSLKKK LTMLQETLNL PPVASETVDR LVLESPAPVE VNLKLRRPSF RDDIDLNATF DVDTPPARPS SSQHGYYEKL CLEKSHSPIQ DVPKKICKGP RKESQLSLGG QSCAGEPDEE LVGAFPIFVR NAILGQKQPK RPRSESSCSK DVVRTGFDGL GGRTKFIQPT DTVMIRPLPV KPKTKVKQRV RVKTVPSLFQ AKLDTFLWS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards