About RNA polymerase II-associated protein 1
RNA polymerase II-associated protein 1 (RPAP1) is a protein
from Homo sapiens identified by UniProt accession
Q9BWH6, 1393 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | RNA polymerase II-associated protein 1 |
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| UniProt accession | Q9BWH6 |
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| Gene | RPAP1 |
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| Organism | Homo sapiens |
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| Length | 1393 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- FEV/FVC ratio · score 0.28
- high density lipoprotein cholesterol measurement · score 0.20
- erythrocyte count · score 0.18
- triglyceride measurement · score 0.17
- total cholesterol measurement · score 0.17
- low density lipoprotein cholesterol measurement · score 0.17
- type 2 diabetes mellitus · score 0.17
- blood protein measurement · score 0.14
- Drugs used in diabetes use measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BWH6-F1 | alphafold | PREDICTED | 74.44 | — |
Amino-acid sequence (1393 residues)
MLSRPKPGES EVDLLHFQSQ FLAAGAAPAV QLVKKGNRGG GDANSDRPPL QDHRDVVMLD NLPDLPPALV PSPPKRARPS PGHCLPEDED PEERLRRHDQ HITAVLTKII ERDTSSVAVN LPVPSGVAFP AVFLRSRDTQ GKSATSGKRS IFAQEIAARR IAEAKGPSVG EVVPNVGPPE GAVTCETPTP RNQGCQLPGS SHSFQGPNLV TGKGLRDQEA EQEAQTIHEE NIARLQAMAP EEILQEQQRL LAQLDPSLVA FLRSHSHTQE QTGETASEEQ RPGGPSANVT KEEPLMSAFA SEPRKRDKLE PEAPALALPV TPQKEWLHMD TVELEKLHWT QDLPPVRRQQ TQERMQARFS LQGELLAPDV DLPTHLGLHH HGEEAERAGY SLQELFHLTR SQVSQQRALA LHVLAQVISR AQAGEFGDRL AGSVLSLLLD AGFLFLLRFS LDDRVDGVIA TAIRALRALL VAPGDEELLD STFSWYHGAL TFPLMPSQED KEDEDEDEEC PAGKAKRKSP EEESRPPPDL ARHDVIKGLL ATSLLPRLRY VLEVTYPGPA VVLDILAVLI RLARHSLESA TRVLECPRLI ETIVREFLPT SWSPVGAGPT PSLYKVPCAT AMKLLRVLAS AGRNIAARLL SSFDLRSRLC RIIAEAPQEL ALPPEEAEML STEALRLWAV AASYGQGGYL YRELYPVLMR ALQVVPRELS THPPQPLSMQ RIASLLTLLT QLTLAAGSTP AETISDSAEA SLSATPSLVT WTQVSGLQPL VEPCLRQTLK LLSRPEMWRA VGPVPVACLL FLGAYYQAWS QQPSSCPEDW LQDMQRLSEE LLLPLLSQPT LGSLWDSLRH CSLLCNPLSC VPALEAPPSL VSLGCSGGCP RLSLAGSASP FPFLTALLSL LNTLAQIHKG LCGQLAAILA APGLQNYFLQ CVAPGAAPHL TPFSAWALRH EYHLQYLALA LAQKAAALQP LPATHAALYH GMALALLSRL LPGSEYLTHE LLLSCVFRLE FLPERTSGGP EAADFSDQLS LGSSRVPRCG QGTLLAQACQ DLPSIRNCYL THCSPARASL LASQALHRGE LQRVPTLLLP MPTEPLLPTD WPFLPLIRLY HRASDTPSGL SPTDTMGTAM RVLQWVLVLE SWRPQALWAV PPAARLARLM CVFLVDSELF RESPVQHLVA ALLAQLCQPQ VLPNLNLDCR LPGLTSFPDL YANFLDHFEA VSFGDHLFGA LVLLPLQRRF SVTLRLALFG EHVGALRALS LPLTQLPVSL ECYTVPPEDN LALLQLYFRT LVTGALRPRW CPVLYAVAVA HVNSFIFSQD PQSSDEVKAA RRSMLQKTWL LADEGLRQHL LHYKLPNSTL PEGFELYSQL PPLRQHYLQR LTSTVLQNGV SET
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