About Poly(A) polymerase gamma
Poly(A) polymerase gamma (PAPOLG) is a protein
from Homo sapiens identified by UniProt accession
Q9BWT3, 736 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Poly(A) polymerase gamma |
|---|
| UniProt accession | Q9BWT3 |
|---|
| Gene | PAPOLG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 736 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- immunoglobulin isotype switching measurement · score 0.23
- asthma · score 0.20
- DNA methylation · score 0.20
- eosinophil count · score 0.12
- endometrial carcinoma · score 0.09
- age at first birth measurement · score 0.08
- schizophrenia · score 0.08
- hepatocellular carcinoma · score 0.07
- Abnormality of refraction · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BWT3-F1 | alphafold | PREDICTED | 74.84 | — |
Amino-acid sequence (736 residues)
MKEMSANTVL DSQRQQKHYG ITSPISLASP KEIDHIYTQK LIDAMKPFGV FEDEEELNHR LVVLGKLNNL VKEWISDVSE SKNLPPSVVA TVGGKIFTFG SYRLGVHTKG ADIDALCVAP RHVERSDFFQ SFFEKLKHQD GIRNLRAVED AFVPVIKFEF DGIEIDLVFA RLAIQTISDN LDLRDDSRLR SLDIRCIRSL NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML GFLGGVSWAM LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI LQGKSDWSKL LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL VGNLERNEFI TLAHVNPQSF PGNKEHHKDN NYVSMWFLGI IFRRVENAES VNIDLTYDIQ SFTDTVYRQA NNINMLKEGM KIEATHVKKK QLHHYLPAEI LQKKKKQSLS DVNRSSGGLQ SKRLSLDSSC LDSSRDTDNG TPFNSPASKS DSPSVGETER NSAEPAAVIV EKPLSVPPAQ GLSIPVIGAK VDSTVKTVSP PTVCTIPTVV GRNVIPRITT PHNPAQGQPH LNGMSNITKT VTPKRSHSPS IDGTPKRLKD VEKFIRLEST FKDPRTAEER KRKSVDAIGG ESMPIPTIDT SRKKRLPSKE LPDSSSPVPA NNIRVIKNSI RLTLNR
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