About Cyclin-dependent kinase 19
Cyclin-dependent kinase 19 (CDK19) is a protein
from Homo sapiens identified by UniProt accession
Q9BWU1, 502 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase 19 |
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| UniProt accession | Q9BWU1 |
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| Gene | CDK19 |
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| Organism | Homo sapiens |
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| Length | 502 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (88)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 87 · score 0.74
- genetic disorder · score 0.41
- undetermined early-onset epileptic encephalopathy · score 0.37
- sex hormone-binding globulin measurement · score 0.29
- risk-taking behaviour · score 0.23
- mean corpuscular hemoglobin concentration · score 0.17
- monocyte count · score 0.12
- Neurodevelopmental disorder · score 0.12
- Microcephaly · score 0.11
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BWU1-F1 | alphafold | PREDICTED | 76.56 | — |
Amino-acid sequence (502 residues)
MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA LKQIEGTGIS MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA EHDLWHIIKF HRASKANKKP MQLPRSMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPFHHD QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ IPYPKREFLN EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ NSTQTNGTAG GAGAGVGGTG AGLQHSQDSS LNQVPPNKKP RLGPSGANSG GPVMPSDYQH SSSRLNYQSS VQGSSQSQST LGYSSSSQQS SQYHPSHQAH RY
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