About Transcriptional repressor scratch 1
Transcriptional repressor scratch 1 (SCRT1) is a protein
from Homo sapiens identified by UniProt accession
Q9BWW7, 348 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Transcriptional repressor scratch 1 |
|---|
| UniProt accession | Q9BWW7 |
|---|
| Gene | SCRT1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 348 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- central nervous system cancer · score 0.03
- neoplasm · score 0.03
- non-small cell lung carcinoma · score 0.02
- Ataxia-telangiectasia · score 0.02
- Fasciitis · score 0.02
- small cell lung carcinoma · score 0.02
- autism · score 0.01
- type 2 diabetes mellitus · score 0.01
- infection · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BWW7-F1 | alphafold | PREDICTED | 52.96 | — |
Amino-acid sequence (348 residues)
MPRSFLVKKV KLDAFSSADL ESAYGRARSD LGAPLHDKGY LSDYVGPSSV YDGDAEAALL KGPSPEPMYA AAVRGELGPA AAGSAPPPTP RPELATAAGG YINGDAAVSE GYAADAFFIT DGRSRRKASN AGAAAAPSTA SAAAPDGDAG GGGGAGGRSL GSGPGGRGGT RAGAGTEARA GPGAAGAGGR HACGECGKTY ATSSNLSRHK QTHRSLDSQL ARRCPTCGKV YVSMPAMAMH LLTHDLRHKC GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH CGKAFADRSN LRAHMQTHSA FKHFQCKRCK KSFALKSYLN KHYESACFKG GAGGPAAPAP PQLSPVQA
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