Apolipoprotein L5 (APOL5)

About Apolipoprotein L5

Apolipoprotein L5 (APOL5) is a protein from Homo sapiens identified by UniProt accession Q9BWW9, 433 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Apolipoprotein L5
UniProt accession	Q9BWW9
Gene	APOL5
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.11
triglyceride measurement · score 0.08
high density lipoprotein cholesterol measurement · score 0.08
IGF-1 measurement · score 0.07
mathematical ability · score 0.06
hepatocellular carcinoma · score 0.00
cancer · score 0.00
schizophrenia · score 0.00
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BWW9-F1	alphafold	PREDICTED	41.09	—

Amino-acid sequence (433 residues)

MPCGKQGNLQ VPGSKVLPGL GEGCKEMWLR KVIYGGEVWG KSPEPEFPSL VNLCQSWKIN NLMSTVHSDE AGMLSYFLFE ELMRCDKDSM PDGNLSEEEK LFLSYFPLHK FELEQNIKEL NTLADQVDTT HELLTKTSLV ASSSGAVSGV MNILGLALAP VTAGGSLMLS ATGTGLGAAA AITNIVTNVL ENRSNSAARD KASRLGPLTT SHEAFGGINW SEIEAAGFCV NKCVKAIQGI KDLHAYQMAK SNSGFMAMVK NFVAKRHIPF WTARGVQRAF EGTTLAMTNG AWVMGAAGAG FLLMKDMSSF LQSWKHLEDG ARTETAEELR ALAKKLEQEL DRLTQHHRHL PQKASQTCSS SRGRAVRGSR VVKPEGSRSP LPWPVVEHQP RLGPGVALRT PKRTVSAPRM LGHQPAPPAP ARKGRQAPGR HRQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards