Transcription factor GATA-5 (GATA5)

About Transcription factor GATA-5

Transcription factor GATA-5 (GATA5) is a protein from Homo sapiens identified by UniProt accession Q9BWX5, 397 residues long. MolForge cross-references it against 0 known binders and 346 disease associations.

Target properties

Protein name	Transcription factor GATA-5
UniProt accession	Q9BWX5
Gene	GATA5
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (346)

Diseases linked to this target (Open Targets).

congenital heart defects, multiple types, 5 · score 0.73
forced expiratory volume · score 0.60
vital capacity · score 0.55
erythrocyte count · score 0.40
familial bicuspid aortic valve · score 0.38
familial atrial fibrillation · score 0.38
Tetralogy of Fallot · score 0.37
FEV/FVC ratio · score 0.37
neurodegenerative disease · score 0.37
platelet count · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BWX5-F1	alphafold	PREDICTED	58.92	—

Amino-acid sequence (397 residues)

MYQSLALAAS PRQAAYADSG SFLHAPGAGS PMFVPPARVP SMLSYLSGCE PSPQPPELAA RPGWAQTATA DSSAFGPGSP HPPAAHPPGA TAFPFAHSPS GPGSGGSAGG RDGSAYQGAL LPREQFAAPL GRPVGTSYSA TYPAYVSPDV AQSWTAGPFD GSVLHGLPGR RPTFVSDFLE EFPGEGRECV NCGALSTPLW RRDGTGHYLC NACGLYHKMN GVNRPLVRPQ KRLSSSRRAG LCCTNCHTTN TTLWRRNSEG EPVCNACGLY MKLHGVPRPL AMKKESIQTR KRKPKTIAKA RGSSGSTRNA SASPSAVAST DSSAATSKAK PSLASPVCPG PSMAPQASGQ EDDSLAPGHL EFKFEPEDFA FPSTAPSPQA GLRGALRQEA WCALALA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards