About Synaptonemal complex protein 2
Synaptonemal complex protein 2 (SYCP2) is a protein
from Homo sapiens identified by UniProt accession
Q9BX26, 1530 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | Synaptonemal complex protein 2 |
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| UniProt accession | Q9BX26 |
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| Gene | SYCP2 |
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| Organism | Homo sapiens |
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| Length | 1530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (163)
Diseases linked to this target (Open Targets).
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.49
- azoospermia · score 0.49
- spermatogenic failure 1 · score 0.38
- neurodegenerative disease · score 0.32
- head and neck squamous cell carcinoma · score 0.23
- breast adenocarcinoma · score 0.22
- self reported educational attainment · score 0.14
- metabolite measurement · score 0.13
- mathematical ability · score 0.12
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BX26-F1 | alphafold | PREDICTED | 53.96 | — |
Amino-acid sequence (1530 residues)
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV DNLICRELNK EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM VAWFEKSKDI IQSQGNSKDE AVLNMIEDLV DLLLVIHDVS DEGKKQVVES FVPRICSLVI DSRVNICIQQ EIIKKMNAML DKMPQDARKI LSNQEMLILM SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHQWF SMDFIAKAFK RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK LLTIILKNTV KISKREGKEL LLYFDASLEI TNVTQKIFGA TKHRESIRKQ GISVAKTSLH ILFDASGSQI LVPESQISPV GEELVSLKEK SKSPKEFAKP SKYIKNSDKG NRNNSQLEKT TPSKRKMSEA SMIVSGADRY TMRSPVLFSN TSIPPRRRRI KPPLQMTSSA EKPSVSQTSE NRVDNAASLK SRSSEGRHRR DNIDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQA AEKRDHTILP GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL TKQKSSSSIS DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP KYSGQKNTEN AKQSDWPVES ETTFKSVLLN KTIEESLIYR KKYILSKDVN TATCDKNPSA SKNVQSHRKA EKELTSELNS WDSKQKKMRE KSKGKEFTNV AESLISQINK RYKTKDDIKS TRKLKESLIN SGFSNKPVVQ LSKEKVQKKS YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD ISWLREPKSK PQLIDYSRNK NVKNHKSGKS RSSLEKGQPS SKMTPSKNIT KKMDKTIPEG RIRLPRKATK TKKNYKDLSN SESECEQEFS HSFKENIPVK EENIHSRMKT VKLPKKQQKV FCAETEKELS KQWKNSSLLK DAIRDNCLDL SPRSLSGSPS SIEVTRCIEK ITEKDFTQDY DCITKSISPY PKTSSLESLN SNSGVGGTIK SPKNNEKNFL CASESCSPIP RPLFLPRHTP TKSNTIVNRK KISSLVLTQE TQNSNSYSDV SSYSSEERFM EIESPHINEN YIQSKREESH LASSLSKSSE GREKTWFDMP CDATHVSGPT QHLSRKRIYI EDNLSNSNEV EMEEKGERRA NLLPKKLCKI EDADHHIHKM SESVSSLSTN DFSIPWETWQ NEFAGIEMTY ETYERLNSEF KRRNNIRHKM LSYFTTQSWK TAQQHLRTMN HQSQDSRIKK LDKFQFIIIE ELENFEKDSQ SLKDLEKEFV DFWEKIFQKF SAYQKSEQQR LHLLKTSLAK SVFCNTDSEE TVFTSEMCLM KEDMKVLQDR LLKDMLEEEL LNVRRELMSV FMSHERNANV
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