Protein LSM14 homolog B (LSM14B)

About Protein LSM14 homolog B

Protein LSM14 homolog B (LSM14B) is a protein from Homo sapiens identified by UniProt accession Q9BX40, 385 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Protein LSM14 homolog B
UniProt accession	Q9BX40
Gene	LSM14B
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.13
Female infertility due to fertilization defect · score 0.07
female infertility due to oocyte meiotic arrest · score 0.07
mean reticulocyte volume · score 0.06
oocyte maturation defect 9 · score 0.06
Hydatidiform Mole · score 0.05
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
hemoglobin D disease · score 0.05
primary ovarian insufficiency · score 0.05
premature ovarian failure 19 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BX40-F1	alphafold	PREDICTED	62.07	—

Amino-acid sequence (385 residues)

MSGSSGTPYL GSKISLISKA QIRYEGILYT IDTDNSTVAL AKVRSFGTED RPTDRPAPPR EEIYEYIIFR GSDIKDITVC EPPKAQHTLP QDPAIVQSSL GSASASPFQP HVPYSPFRGM APYGPLAASS LLSQQYAASL GLGAGFPSIP VGKSPMVEQA VQTGSADNLN AKKLLPGKGT TGTQLNGRQA QPSSKTASDV VQPAAVQAQG QVNDENRRPQ RRRSGNRRTR NRSRGQNRPT NVKENTIKFE GDFDFESANA QFNREELDKE FKKKLNFKDD KAEKGEEKDL AVVTQSAEAP AEEDLLGPNC YYDKSKSFFD NISSELKTSS RRTTWAEERK LNTETFGVSG RFLRGRSSRG GFRGGRGNGT TRRNPTSHRA GTGRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards