Junctional adhesion molecule C (JAM3)

About Junctional adhesion molecule C

Junctional adhesion molecule C (JAM3) is a protein from Homo sapiens identified by UniProt accession Q9BX67, 310 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.

Target properties

Protein name	Junctional adhesion molecule C
UniProt accession	Q9BX67
Gene	JAM3
Organism	Homo sapiens
Length	310 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (278)

Diseases linked to this target (Open Targets).

porencephaly-microcephaly-bilateral congenital cataract syndrome · score 0.79
neutrophil count · score 0.45
blood protein measurement · score 0.38
cortical thickness · score 0.37
cortical surface area measurement · score 0.32
leukocyte count · score 0.31
protein measurement · score 0.30
schizophrenia · score 0.25
breast adenocarcinoma · score 0.25
pancreatic adenocarcinoma · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BX67-F1	alphafold	PREDICTED	85.04	—

Amino-acid sequence (310 residues)

MALRRPPRLR LCARLPDFFL LLLFRGCLIG AVNLKSSNRT PVVQEFESVE LSCIITDSQT SDPRIEWKKI QDEQTTYVFF DNKIQGDLAG RAEILGKTSL KIWNVTRRDS ALYRCEVVAR NDRKEIDEIV IELTVQVKPV TPVCRVPKAV PVGKMATLHC QESEGHPRPH YSWYRNDVPL PTDSRANPRF RNSSFHLNSE TGTLVFTAVH KDDSGQYYCI ASNDAGSARC EEQEMEVYDL NIGGIIGGVL VVLAVLALIT LGICCAYRRG YFINNKQDGE SYKNPGKPDG VNYIRTDEEG DFRHKSSFVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards