About Caspase recruitment domain-containing protein 6
Caspase recruitment domain-containing protein 6 (CARD6) is a protein
from Homo sapiens identified by UniProt accession
Q9BX69, 1037 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Caspase recruitment domain-containing protein 6 |
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| UniProt accession | Q9BX69 |
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| Gene | CARD6 |
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| Organism | Homo sapiens |
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| Length | 1037 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- Spinal cord injury · score 0.07
- erythrocyte count · score 0.03
- Eczematoid dermatitis · score 0.03
- multiple sclerosis · score 0.02
- Crohn's disease · score 0.02
- allergic rhinitis · score 0.02
- esophageal squamous cell carcinoma · score 0.02
- seasonal allergic rhinitis · score 0.02
- hematocrit · score 0.02
- hemoglobin measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BX69-F1 | alphafold | PREDICTED | 54.86 | — |
Amino-acid sequence (1037 residues)
MATESTPSEI IERERKKLLE ILQHDPDSIL DTLTSRRLIS EEEYETLENV TDLLKKSRKL LILVQKKGEA TCQHFLKCLF STFPQSAAIC GLRHEVLKHE NTVPPQSMGA SSNSEDAFSP GIKQPEAPEI TVFFSEKEHL DLETSEFFRD KKTSYRETAL SARKNEKEYD TPEVTLSYSV EKVGCEVPAT ITYIKDGQRY EELDDSLYLG KEEYLGSVDT PEDAEATVEE EVYDDPEHVG YDGEEDFENS ETTEFSGEEP SYEGSETSLS LEEEQEKSIE ERKKVFKDVL LCLNMDRSRK VLPDFVKQFS LDRGCKWTPE SPGDLAWNFL MKVQARDVTA RDSILSHKVL DEDSKEDLLA GVENLEIRDI QTINPLDVLC ATMLCSDSSL QRQVMSNMYQ CQFALPLLLP DAENNKSILM LGAMKDIVKK QSTQFSGGPT EDTEKFLTLM KMPVISFVRL GYCSFSKSRI LNTLLSPAQL KLHKIFLHQD LPLLVLPRQI SDGLVEITWC FPDSDDRKEN PFFQKPVALA NLRGNLESFW TQFGFLMEVS SAVFFFTDCL GEKEWDLLMF LGEAAIERCY FVLSSQARES EEAQIFQRIL NLKPAQLLFW ERGDAGDRRK NMEGLQAALQ EVMFSSCLRC VSVEDMAALA RELGIQVDED FENTQRIQVS SGENMAGTAE GEGQQRHSQL KSSSKSQALM PIQEPGTQCE LSQNLQNLYG TPVFRPVLEN SWLFPTRIGG NFNHVSLKAS WVMGRPFGSE QRPKWFHPLP FQNAGAQGRG KSFGIQSFHP QIFYSGERFM KFSRVARGCH SNGTFGRLPR PICQHVQACP ERPQMMGTLE RSRAVASKIG HSYSLDSQPA RAVGKPWPQQ ACTRVTELTE ATGKLIRTSH IGKPHPQSFQ PAAATQKLRP ASQQGVQMKT QGGASNPALQ IGSHPMCKSS QFKSDQSNPS TVKHSQPKPF HSVPSQPKSS QTKSCQSQPS QTKPSPCKST QPKPSQPWPP QSKPSQPRPP QPKSSSTNPS QAKAHHSKAG QKRGGKH
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