BTB/POZ domain-containing protein 2 (BTBD2)

About BTB/POZ domain-containing protein 2

BTB/POZ domain-containing protein 2 (BTBD2) is a protein from Homo sapiens identified by UniProt accession Q9BX70, 525 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein 2
UniProt accession	Q9BX70
Gene	BTBD2
Organism	Homo sapiens
Length	525 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

platelet count · score 0.42
mean platelet volume · score 0.37
platelet component distribution width · score 0.34
platelet crit · score 0.09
body mass index · score 0.09
Red cell distribution width · score 0.05
C-reactive protein measurement · score 0.05
dehydrated hereditary stomatocytosis · score 0.05
HIV-1 infection · score 0.05
sideroblastic anemia 3 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BX70-F1	alphafold	PREDICTED	82.64	—

Amino-acid sequence (525 residues)

MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA AAAAPGPTPP APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK PTVQERFAFL FNNEVLCDVH FLVGKGLSSQ RIPAHRFVLA VGSAVFDAMF NGGMATTSTE IELPDVEPAA FLALLKFLYS DEVQIGPETV MTTLYTAKKY AVPALEAHCV EFLKKNLRAD NAFMLLTQAR LFDEPQLASL CLENIDKNTA DAITAEGFTD IDLDTLVAVL ERDTLGIREV RLFNAVVRWS EAECQRQQLQ VTPENRRKVL GKALGLIRFP LMTIEEFAAG PAQSGILVDR EVVSLFLHFT VNPKPRVEFI DRPRCCLRGK ECSINRFQQV ESRWGYSGTS DRIRFSVNKR IFVVGFGLYG SIHGPTDYQV NIQIIHTDSN TVLGQNDTGF SCDGSASTFR VMFKEPVEVL PNVNYTACAT LKGPDSHYGT KGLRKVTHES PTTGAKTCFT FCYAAGNNNG TSVEDGQIPE VIFYT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards