About TM2 domain-containing protein 1
TM2 domain-containing protein 1 (TM2D1) is a protein
from Homo sapiens identified by UniProt accession
Q9BX74, 207 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | TM2 domain-containing protein 1 |
|---|
| UniProt accession | Q9BX74 |
|---|
| Gene | TM2D1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 207 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (101)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.44
- platelet count · score 0.41
- myeloid white cell count · score 0.36
- platelet crit · score 0.35
- lymphocyte count · score 0.34
- neurodegenerative disease · score 0.30
- leukocyte count · score 0.29
- monocyte percentage of leukocytes · score 0.28
- hip bone size · score 0.27
- JT interval · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BX74-F1 | alphafold | PREDICTED | 82.04 | — |
Amino-acid sequence (207 residues)
MAAAWPSGPS APEAVTARLV GVLWFVSVTT GPWGAVATSA GGEESLKCED LKVGQYICKD PKINDATQEP VNCTNYTAHV SCFPAPNITC KDSSGNETHF TGNEVGFFKP ISCRNVNGYS YKVAVALSLF LGWLGADRFY LGYPALGLLK FCTVGFCGIG SLIDFILISM QIVGPSDGSS YIIDYYGTRL TRLSITNETF RKTQLYP
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