Sphingosine-1-phosphate phosphatase 1 (SGPP1)

About Sphingosine-1-phosphate phosphatase 1

Sphingosine-1-phosphate phosphatase 1 (SGPP1) is a protein from Homo sapiens identified by UniProt accession Q9BX95, 441 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Sphingosine-1-phosphate phosphatase 1
UniProt accession	Q9BX95
Gene	SGPP1
Organism	Homo sapiens
Length	441 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
sphingomyelin measurement · score 0.08
mean platelet volume · score 0.07
colorectal carcinoma · score 0.07
Red cell distribution width · score 0.07
Miyoshi myopathy · score 0.07
low density lipoprotein cholesterol measurement · score 0.07
breast cancer · score 0.06
serum metabolite measurement · score 0.06
sphingolipid measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BX95-F1	alphafold	PREDICTED	80.76	—

Amino-acid sequence (441 residues)

MSLRQRLAQL VGRLQDPQKV ARFQRLCGVE APPRRSADRR EDEKAEAPLA GDPRLRGRQP GAPGGPQPPG SDRNQCPAKP DGGGAPNGVR NGLAAELGPA SPRRAGALRR NSLTGEEGQL ARVSNWPLYC LFCFGTELGN ELFYILFFPF WIWNLDPLVG RRLVVIWVLV MYLGQCTKDI IRWPRPASPP VVKLEVFYNS EYSMPSTHAM SGTAIPISMV LLTYGRWQYP LIYGLILIPC WCSLVCLSRI YMGMHSILDI IAGFLYTILI LAVFYPFVDL IDNFNQTHKY APFIIIGLHL ALGIFSFTLD TWSTSRGDTA EILGSGAGIA CGSHVTYNMG LVLDPSLDTL PLAGPPITVT LFGKAILRIL IGMVFVLIIR DVMKKITIPL ACKIFNIPCD DIRKARQHME VELPYRYITY GMVGFSITFF VPYIFFFIGI S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards