About Oxysterol-binding protein-related protein 10
Oxysterol-binding protein-related protein 10 (OSBPL10) is a protein
from Homo sapiens identified by UniProt accession
Q9BXB5, 764 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Oxysterol-binding protein-related protein 10 |
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| UniProt accession | Q9BXB5 |
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| Gene | OSBPL10 |
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| Organism | Homo sapiens |
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| Length | 764 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.30
- arterial stiffness measurement · score 0.29
- sleep duration · score 0.23
- triglyceride measurement · score 0.23
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- protein measurement · score 0.17
- adolescent idiopathic scoliosis · score 0.16
- coronary artery disease · score 0.14
- early-onset non-syndromic cataract · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXB5-F1 | alphafold | PREDICTED | 73.31 | — |
Amino-acid sequence (764 residues)
MERAVQGTDG GGGSNSSSRS SSRATSAGSS PSCSLAGRGV SSRSAAAGLG GGGSRSSPGS VAASPSGGGG RRREPALEGV LSKYTNLLQG WQNRYFVLDF EAGILQYFVN EQSKHQKPRG VLSLSGAIVS LSDEAPHMLV VYSANGEMFK LRAADAKEKQ FWVTQLRACA KYHMEMNSKS APSSRSRSLT LLPHGTPNSA SPCSQRHLSV GAPGVVTITH HKSPAAARRA KSQYSGQLHE VREMMNQVEG QQKNLVHAIE SLPGSGPLTA LDQDLLLLKA TSAATLSCLG ECLNLLQQSV HQAGQPSQKP GASENILGWH GSKSHSTEQL KNGTLGSLPS ASANITWAIL PNSAEDEQTS QPEPEPNSGS ELVLSEDEKS DNEDKEETEL GVMEDQRSII LHLISQLKLG MDLTKVVLPT FILEKRSLLE MYADFMAHPD LLLAITAGAT PEERVICFVE YYLTAFHEGR KGALAKKPYN PIIGETFHCS WEVPKDRVKP KRTASRSPAS CHEHPMADDP SKSYKLRFVA EQVSHHPPIS CFYCECEEKR LCVNTHVWTK SKFMGMSVGV SMIGEGVLRL LEHGEEYVFT LPSAYARSIL TIPWVELGGK VSINCAKTGY SATVIFHTKP FYGGKVHRVT AEVKHNPTNT IVCKAHGEWN GTLEFTYNNG ETKVIDTTTL PVYPKKIRPL EKQGPMESRN LWREVTRYLR LGDIDAATEQ KRHLEEKQRV EERKRENLRT PWKPKYFIQE GDGWVYFNPL WKAH
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