About Spermatogenesis-associated protein 16
Spermatogenesis-associated protein 16 (SPATA16) is a protein
from Homo sapiens identified by UniProt accession
Q9BXB7, 569 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Spermatogenesis-associated protein 16 |
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| UniProt accession | Q9BXB7 |
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| Gene | SPATA16 |
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| Organism | Homo sapiens |
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| Length | 569 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- male infertility due to globozoospermia · score 0.39
- cortical thickness · score 0.38
- cortical surface area measurement · score 0.38
- neurodegenerative disease · score 0.38
- brain measurement · score 0.31
- temporal horn of lateral ventricle volume measurement · score 0.29
- Globozoospermia · score 0.20
- azoospermia · score 0.19
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXB7-F1 | alphafold | PREDICTED | 72.31 | — |
Amino-acid sequence (569 residues)
MDAGSSRSLE NAVNRIYHDQ LVPKINTSKK MSTLAHPPNI LEMSQEIKKN CGGKQVEITL ERTKMTKGIK EKQSNDLEKA AFKRKAEGEE KPTRKKQAKI TELDNQLITM PLPHIPLKNI MDVEMKLVYI DEMGVRYEFV ESFMSTGSQP TCQAAEIVDP LSVHNFSFLP QIDKWLQVAL KDASSCYRQK KYALAAGQFR TALELCSKGA VLGEPFDAPA EDIASVASFI ETKLVTCYLR MRKPDLALNH AHRSIVLNPA YFRNHLRQAT VFRCLERYSE AARSAMIADY MFWLGGGREE SISKLIKLYW QAMIEEAITR AESFSVMYTP FATKIRADKI EKVKDAFTKT HPAYAEYMYT DLQALHMLPQ TVDWSSFPPQ QYLLTLGFKN KDDGKFLEKI SSRKLPIFTE HKTPFGLTRE DTVRQMETMG KRILPILDFI RSTQLNGSFP ASSGVMEKLQ YASLLSQLQR VKEQSQVINQ AMAELATIPY LQDISQQEAE LLQSLMADAM DTLEGRRNNN ERVWNMIQKV GQIEDFLYQL EDSFLKTKKL RTARRQKTKM KRLQTVQQR
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