About Spermatogenic leucine zipper protein 1
Spermatogenic leucine zipper protein 1 (SPZ1) is a protein
from Homo sapiens identified by UniProt accession
Q9BXG8, 430 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Spermatogenic leucine zipper protein 1 |
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| UniProt accession | Q9BXG8 |
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| Gene | SPZ1 |
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| Organism | Homo sapiens |
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| Length | 430 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- amyloid-beta measurement · score 0.22
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.09
- sickle cell anemia · score 0.03
- hepatorenocardiac degenerative fibrosis · score 0.03
- congenital dyserythropoietic anemia type 4 · score 0.03
- Congenital dyserythropoietic anemia type IV · score 0.03
- Recurrent infections-myelofibrosis-nephromegaly syndrome · score 0.03
- hemoglobin D disease · score 0.03
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXG8-F1 | alphafold | PREDICTED | 67.62 | — |
Amino-acid sequence (430 residues)
MASSAKSAEM PTISKTVNPT PDPHQEYLDP RITIALFEIG SHSPSSWGSL PFLKNSSHQV TEQQTAQKFN NLLKEIKDIL KNMAGFEEKI TEAKELFEET NITEDVSAHK ENIRGLDKIN EMLSTNLPVS LAPEKEDNEK KQEMILETNI TEDVSAHKEN IRGLDKINEM LSTNLPVSLA PEKEDNEKKQ QMIMENQNSE NTAQVFARDL VNRLEEKKVL NETQQSQEKA KNRLNVQEET MKIRNNMEQL LQEAEHWSKQ HTELSKLIKS YQKSQKDISE TLGNNGVGFQ TQPNNEVSAK HELEEQVKKL SHDTYSLQLM AALLENECQI LQQRVEILKE LHHQKQGTLQ EKPIQINYKQ DKKNQKPSEA KKVEMYKQNK QAMKGTFWKK DRSCRSLDVC LNKKACNTQF NIHVARKALR GKMRSASSLR
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