Mitochondrial ornithine transporter 2 (SLC25A2)

About Mitochondrial ornithine transporter 2

Mitochondrial ornithine transporter 2 (SLC25A2) is a protein from Homo sapiens identified by UniProt accession Q9BXI2, 301 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Mitochondrial ornithine transporter 2
UniProt accession	Q9BXI2
Gene	SLC25A2
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.18
squamous cell lung carcinoma · score 0.13
gastric adenocarcinoma · score 0.09
actinic keratosis · score 0.04
Gout · score 0.01
type 2 diabetes mellitus · score 0.01
ornithine translocase deficiency · score 0.01
urea cycle disorder · score 0.01
coronary artery disease · score 0.01
Hyperammonemia · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BXI2-F1	alphafold	PREDICTED	88.42	—

Amino-acid sequence (301 residues)

MKSGPGIQAA IDLTAGAAGG TACVLTGQPF DTIKVKMQTF PDLYKGLTDC FLKTYAQVGL RGFYKGTGPA LMAYVAENSV LFMCYGFCQQ FVRKVAGMDK QAKLSDLQTA AAGSFASAFA ALALCPTELV KCRLQTMYEM EMSGKIAKSH NTIWSVVKGI LKKDGPLGFY HGLSSTLLQE VPGYFFFFGG YELSRSFFAS GRSKDELGPV HLMLSGGVAG ICLWLVVFPV DCIKSRIQVL SMYGKQAGFI GTLLSVVRNE GIVALYSGLK ATMIRAIPAN GALFVAYEYS RKMMMKQLEA Y

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards