About Serine/threonine-protein kinase PINK1, mitochondrial
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) is a protein
from Homo sapiens identified by UniProt accession
Q9BXM7, 581 residues long.
MolForge cross-references it against 0 known binders and
463 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase PINK1, mitochondrial |
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| UniProt accession | Q9BXM7 |
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| Gene | PINK1 |
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| Organism | Homo sapiens |
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| Length | 581 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (463)
Diseases linked to this target (Open Targets).
- Young adult-onset Parkinsonism · score 0.82
- Dystonia · score 0.51
- Parkinson disease · score 0.41
- young-onset Parkinson disease · score 0.37
- genetic disorder · score 0.19
- neuroblastoma · score 0.14
- Hereditary late-onset Parkinson disease · score 0.14
- leprosy · score 0.13
- acute kidney failure · score 0.10
- cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXM7-F1 | alphafold | PREDICTED | 77.25 | — |
Amino-acid sequence (581 residues)
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L
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