About Solute carrier family 12 member 9
Solute carrier family 12 member 9 (SLC12A9) is a protein
from Homo sapiens identified by UniProt accession
Q9BXP2, 914 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Solute carrier family 12 member 9 |
|---|
| UniProt accession | Q9BXP2 |
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| Gene | SLC12A9 |
|---|
| Organism | Homo sapiens |
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| Length | 914 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- hair colour measurement · score 0.59
- hair color · score 0.18
- sex hormone-binding globulin measurement · score 0.17
- pulse pressure measurement · score 0.12
- diastolic blood pressure · score 0.11
- hypertension · score 0.10
- total cholesterol measurement · score 0.10
- platelet component distribution width · score 0.09
- inflammatory bowel disease · score 0.08
- alkaline phosphatase measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXP2-F1 | alphafold | PREDICTED | 81.26 | — |
Amino-acid sequence (914 residues)
MASESSPLLA YRLLGEEGVA LPANGAGGPG GASARKLSTF LGVVVPTVLS MFSIVVFLRI GFVVGHAGLL QALAMLLVAY FILALTVLSV CAIATNGAVQ GGGAYFMISR TLGPEVGGSI GLMFYLANVC GCAVSLLGLV ESVLDVFGAD ATGPSGLRVL PQGYGWNLLY GSLLLGLVGG VCTLGAGLYA RASFLTFLLV SGSLASVLIS FVAVGPRDIR LTPRPGPNGS SLPPRFGHFT GFNSSTLKDN LGAGYAEDYT TGAVMNFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL GTIVAVAYTF FVYVLLFFLS SFTCDRTLLQ EDYGFFRAIS LWPPLVLIGI YATALSASMS SLIGASRILH ALARDDLFGV ILAPAKVVSR GGNPWAAVLY SWGLVQLVLL AGKLNTLAAV VTVFYLVAYA AVDLSCLSLE WASAPNFRPT FSLFSWHTCL LGVASCLLMM FLISPGAAGG SLLLMGLLAA LLTARGGPSS WGYVSQALLF HQVRKYLLRL DVRKDHVKFW RPQLLLLVGN PRGALPLLRL ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD RAQVKAFVDL TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAPPQDH FLTDPAFSEP ADSTREGSSP ALSTLFPPPR APGSPRALNP QDYVATVADA LKMNKNVVLA RASGALPPER LSRGSGGTSQ LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ MATILGMVPA WHSARLRIFL CLGPREAPGA AEGRLRALLS QLRIRAEVQE VVWGEGAGAG EPEAEEEGDF VNSGRGDAEA EALARSANAL VRAQQGRGTG GGPGGPEGGD AEGPITALTF LYLPRPPADP ARYPRYLALL ETLTRDLGPT LLVHGVTPVT CTDL
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