About Queuine tRNA-ribosyltransferase catalytic subunit 1
Queuine tRNA-ribosyltransferase catalytic subunit 1 (QTRT1) is a protein
from Homo sapiens identified by UniProt accession
Q9BXR0, 403 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Queuine tRNA-ribosyltransferase catalytic subunit 1 |
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| UniProt accession | Q9BXR0 |
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| Gene | QTRT1 |
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| Organism | Homo sapiens |
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| Length | 403 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- forced expiratory volume · score 0.21
- skin disease · score 0.16
- waist-hip ratio · score 0.13
- BMI-adjusted waist-hip ratio · score 0.10
- total blood protein measurement · score 0.09
- serum non-albumin protein measurement · score 0.08
- lung adenocarcinoma · score 0.08
- psoriasis · score 0.07
- inflammatory bowel disease · score 0.06
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXR0-F1 | alphafold | PREDICTED | 93.66 | — |
Amino-acid sequence (403 residues)
MAGAATQASL ESAPRIMRLV AECSRSRARA GELWLPHGTV ATPVFMPVGT QATMKGITTE QLDALGCRIC LGNTYHLGLR PGPELIQKAN GLHGFMNWPH NLLTDSGGFQ MVSLVSLSEV TEEGVRFRSP YDGNETLLSP EKSVQIQNAL GSDIIMQLDD VVSSTVTGPR VEEAMYRSIR WLDRCIAAHQ RPDKQNLFAI IQGGLDADLR ATCLEEMTKR DVPGFAIGGL SGGESKSQFW RMVALSTSRL PKDKPRYLMG VGYATDLVVC VALGCDMFDC VFPTRTARFG SALVPTGNLQ LRKKVFEKDF GPIDPECTCP TCQKHSRAFL HALLHSDNTA ALHHLTVHNI AYQLQLMSAV RTSIVEKRFP DFVRDFMGAM YGDPTLCPTW ATDALASVGI TLG
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