Tudor domain-containing protein 1 (TDRD1)

About Tudor domain-containing protein 1

Tudor domain-containing protein 1 (TDRD1) is a protein from Homo sapiens identified by UniProt accession Q9BXT4, 1180 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Tudor domain-containing protein 1
UniProt accession	Q9BXT4
Gene	TDRD1
Organism	Homo sapiens
Length	1180 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.33
male infertility · score 0.27
von Willebrand factor measurement · score 0.23
blood protein measurement · score 0.22
total blood protein measurement · score 0.22
insomnia · score 0.22
mean corpuscular volume · score 0.21
lean body mass · score 0.21
monocyte count · score 0.17
leukocyte count · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BXT4-F1	alphafold	PREDICTED	71.33	—

Amino-acid sequence (1180 residues)

MSVKSPFNVM SRNNLEAPPC KMTEPFNFEK NENKLPPHES LRSPGTLPNH PNFRLKSSEN GNKKNNFLLC EQTKQYLASQ EDNSVSSNPN GINGEVVGSK GDRKKLPAGN SVSPPSAESN SPPKEVNIKP GNNVRPAKSK KLNKLVENSL SISNPGLFTS LGPPLRSTTC HRCGLFGSLR CSQCKQTYYC STACQRRDWS AHSIVCRPVQ PNFHKLENKS SIETKDVEVN NKSDCPLGVT KEIAIWAERI MFSDLRSLQL KKTMEIKGTV TEFKHPGDFY VQLYSSEVLE YMNQLSASLK ETYANVHEKD YIPVKGEVCI AKYTVDQTWN RAIIQNVDVQ QKKAHVLYID YGNEEIIPLN RIYHLNRNID LFPPCAIKCF VANVIPAEGN WSSDCIKATK PLLMEQYCSI KIVDILEEEV VTFAVEVELP NSGKLLDHVL IEMGYGLKPS GQDSKKENAD QSDPEDVGKM TTENNIVVDK SDLIPKVLTL NVGDEFCGVV AHIQTPEDFF CQQLQSGRKL AELQASLSKY CDQLPPRSDF YPAIGDICCA QFSEDDQWYR ASVLAYASEE SVLVGYVDYG NFEILSLMRL CPIIPKLLEL PMQAIKCVLA GVKPSLGIWT PEAICLMKKL VQNKIITVKV VDKLENSSLV ELIDKSETPH VSVSKVLLDA GFAVGEQSMV TDKPSDVKET SVPLGVEGKV NPLEWTWVEL GVDQTVDVVV CVIYSPGEFY CHVLKEDALK KLNDLNKSLA EHCQQKLPNG FKAEIGQPCC AFFAGDGSWY RALVKEILPN GHVKVHFVDY GNIEEVTADE LRMISSTFLN LPFQGIRCQL ADIQSRNKHW SEEAITRFQM CVAGIKLQAR VVEVTENGIG VELTDLSTCY PRIISDVLID EHLVLKSASP HKDLPNDRLV NKHELQVHVQ GLQATSSAEQ WKTIELPVDK TIQANVLEII SPNLFYALPK GMPENQEKLC MLTAELLEYC NAPKSRPPYR PRIGDACCAK YTSDDFWYRA VVLGTSDTDV EVLYADYGNI ETLPLCRVQP ITSSHLALPF QIIRCSLEGL MELNGSSSQL IIMLLKNFML NQNVMLSVKG ITKNVHTVSV EKCSENGTVD VADKLVTFGL AKNITPQRQS ALNTEKMYRM NCCCTELQKQ VEKHEHILLF LLNNSTNQNK FIEMKKLLKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards