About Testis-expressed protein 15
Testis-expressed protein 15 (TEX15) is a protein
from Homo sapiens identified by UniProt accession
Q9BXT5, 2789 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | Testis-expressed protein 15 |
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| UniProt accession | Q9BXT5 |
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| Gene | TEX15 |
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| Organism | Homo sapiens |
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| Length | 2789 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (131)
Diseases linked to this target (Open Targets).
- spermatogenic failure 25 · score 0.70
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.46
- azoospermia · score 0.42
- head and neck squamous cell carcinoma · score 0.23
- breast adenocarcinoma · score 0.22
- lung adenocarcinoma · score 0.19
- type 2 diabetes mellitus · score 0.12
- genetic disorder · score 0.12
- ovarian cancer · score 0.12
- myoepithelial tumor · score 0.11
3D Structure (8)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (2789 residues)
MPSDAKDSVN GDLLLNWTSL KNILSGLNAS FPLHNNTGSS TVTTSKSIKD PRLMRREESM GEQSSTAGLN EVLQFEKSSD NVNSEIKSTP SNSASSSEVV PGDCAVLTNG LDTPCFKTSV NDSQSWAHNM GSEDYDCIPP NKVTMAGQCK DQGNFSFPIS VSNVVSEVEN QNHSEEKAQR AQQESGNAYT KEYSSHIFQD SQSSDLKTIY QTGCQTSTVF PLKKKVSIDE YLQNTGKMKN FADLEDSSKH EEKQTSWKEI DNDFTNETKI SPIDNYIVLH QEYKESESHN SFGKSCDKIL ITQELEITKS STSTIKDKDE LDHLALEWQI TPSFESLSQK HPQHSVEYEG NIHTSLAIAQ KLMELKLGKI NQNYASIITE AFPKPKDIPQ AKEMFIDTVI SSYNIETAHD SSNCSITREH ICVHRKNENE PVSLENIQRD YKETAYVEDR GQDHNLFCNS QLSNDIWLNV NFKKQTDREN QNEAKENSAS CVENNIENIY GDKKQDSHTN ENFSNIDEKE DKNYHNIEIL SSEEFSTKFN LICREDNAVS AATALLESEE DTISAVKQKD TENTGRSVEH LASTTFPKTA SSSVCVASNA AIQIASATMP ALSLNNDDHQ IYQFKETCSS ESPDFGLLVK HRVSDCEIDT DKNKSQESFH QSINENLVLQ SIELESEIEI ELEDCDDAFI FQQDTHSHEN MLCEEFVTSY KALKSRISWE GLLALDNGEM EVLESTTGRE NSDQHYSKES NYFYSSTQNN ETELTSPILL PDLQIKITNI FRPGFSPTAD SLALKDSFCT HVTEATKPEI NKEDGEILGF DIYSQPFGEN ADYPCEDKVD NIRQESGPVS NSEISLSFDL SRNTDVNHTS ENQNSESLFT EPSNVTTIDD GSRCFFTKSK TDYNDTKNKK EVESRISKRK LHISSRDQNI PHKDLRRHKI YGRKRRLTSQ DSSECFSSLS QGRIKTFSQS EKHIKSVLNI LSDEASLCKS KCLSRKLDKA VVHLKKAHRR VHTSLQLITK VGEERKGPLP KSYAIICNNF WESCDLQGYS SVSQRKYYST KHFSSKRKYD KRRKKRAPKA DISKSLTHVS KHKSYKTSGE KKCLSRKSMA SSVSKSHPTT SHMGEFCNQE HPESQLPVSS TSQSTSQSVY YNSSVSNPSL SEEHQPFSGK TAYLFSPDHS DEKLIEKENQ IDTAFLSSTS KYEKLEKHSA NHNVKDATKE NSCDANEVIN ESNSVSLSCI KENINSSTGN DCDATCIGHT KAKTDVLISV LDSNVKHFLN DLYQQGNLIL SDCKRNLEVK WTDPIERPKQ NIITGNFLMG PLNLTLIASK KYSIPQLSAA AVTDSEGESS KSYLDKQRIL TVDSFAASST VPHCEQSCRE KELLKTEQCS SGNCLHTDGN ETNVTENYEL DVASGTEEDK SYGENIVELS SSDSSLLLKD NVKGSSSETC IVKKDTEDRI TWKVKQAEKA KDSVYKRSMT EGSTVNTEYK NQKNQISEES CLNEKIITTN LIDSHLSTKN TTTESVPLKN TVSNPLNKRE KKGEIKVSKD SQSDLTLHSE IAYISKPGIL GVNHTPILPA HSETCKVPTL LKKPASYVSD FKEKHCSANH TALIANLSQI LQRADEASSL QILQEETKVC LNILPLFVEA FERKQECSVE QILISRELLV DQNLWNNCKH TLKPCAVDTL VELQMMMETI QFIENKKRHL EGEPTLRSLL WYDETLYAEL LGKPRGFQQQ SNFYPGFQGR LKYNAFCELQ TYHDQLVELL EETKREKNSY YVFLKYKRQV NECEAIMEHC SDCFDFSLSV PFTCGVNFGD SLEDLEILRK STLKLINVCG DSPKVHSYPG KQDHLWIIIE MISSKVNFIK NNEAVRVKIS LYGLEHIFFD AAKNLVWKER TQSFSKKYSQ KKDEERLLRV NKCAFSKLQK IYDTLSKDLN NEPISPIGLE EDTIIASRKS DHPINEATIS IENSKFNSNL LAHPDICCIS EILDQAEFAD LKKLQDLTLR CTDHLEILKK YFQMLQDNNM DNIFITEENV LDVVINHSHE AIILKPEAIE MYIEIVMVSE TIHFLKNSIA KKLDKQRFRG MLWFDLSLLP ELVQCQEKMA SFSFLKDNST DVCLWKVIET AVSELKKDLD IICKYNEAVN CSYAIHLLSR ELQELSEIKK LLKKSKYFIS TYIDFVPYIA SINYGSTVTE LEYNYNQFST LLKNVMSAPR KDLGKMAHIR KVMKTIEHMK MICTKNAELT ISFFLCQMLY NRRKILQLKR KEKMNIHIVK PGENNNKFSI STMLPPVSEC INKNISNSSK KRPSTVDKCE DSQEQQQDTT VSSCKKLKVD MKDVTKINRE KATFKHPRTT GSHPKSENKI VPSSCDSLKR NHLTPKKVEM QRSLPGSLLP LENPKDTCAS KSESKIDLTV SSDHFSGQQE NLNSMKKRNV NFSAAETKSD KKDCAAFAIC DQKSVHGTFS PDHGTLLQKF LKNSPDPTQK SCLSDINPET DVSLVPDASV LSKPIFCFVK DVHPDLEMND TVFELQDNDI VNSSIKNSSC MTSPEPICIQ NKIPTLQINK LQPTETESED KYMKDTLNPN TVHTFGASGH ITLNVNQGAE YSLSEQQNDK NSKVLMQNAA TYWNELPQSA CNPTYNSSEH LFGTSYPYSA WCVYQYSNSN GNAITQTYQG ITSYEVQPSP SGLLTTVAST AQGTHSNLLY SQYFTYFAGE PQANGFVPVN GYFQSQIPAS NFRQPIFSQY ASHQPLPQAT YPYLPNRFVP PEVPWVYAPW HQESFHPGH
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