About R-spondin-3
R-spondin-3 (RSPO3) is a protein
from Homo sapiens identified by UniProt accession
Q9BXY4, 272 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | R-spondin-3 |
|---|
| UniProt accession | Q9BXY4 |
|---|
| Gene | RSPO3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 272 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (294)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.55
- high density lipoprotein cholesterol measurement · score 0.53
- bone quantitative ultrasound measurement · score 0.52
- heel bone mineral density · score 0.52
- BMI-adjusted waist circumference · score 0.52
- waist-hip ratio · score 0.51
- triglyceride measurement · score 0.51
- smoking behavior · score 0.50
- hemoglobin measurement · score 0.50
- physical activity measurement · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BXY4-F1 | alphafold | PREDICTED | 78.70 | — |
Amino-acid sequence (272 residues)
MHLRLISWLF IILNFMEYIG SQNASRGRRQ RRMHPNVSQG CQGGCATCSD YNGCLSCKPR LFFALERIGM KQIGVCLSSC PSGYYGTRYP DINKCTKCKA DCDTCFNKNF CTKCKSGFYL HLGKCLDNCP EGLEANNHTM ECVSIVHCEV SEWNPWSPCT KKGKTCGFKR GTETRVREII QHPSAKGNLC PPTNETRKCT VQRKKCQKGE RGKKGRERKR KKPNKGESKE AIPDSKSLES SKEIPEQREN KQQQKKRKVQ DKQKSVSVST VH
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