Solute carrier family 46 member 2 (SLC46A2)

About Solute carrier family 46 member 2

Solute carrier family 46 member 2 (SLC46A2) is a protein from Homo sapiens identified by UniProt accession Q9BY10, 475 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Solute carrier family 46 member 2
UniProt accession	Q9BY10
Gene	SLC46A2
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

hematocrit · score 0.38
hemoglobin measurement · score 0.34
red blood cell density measurement · score 0.27
erythrocyte count · score 0.16
neurofibrillary tangles measurement · score 0.06
PHF-tau measurement · score 0.06
blood protein measurement · score 0.04
short-limb skeletal dysplasia with severe combined immunodeficiency · score 0.03
non-small cell lung carcinoma · score 0.03
neoplasm · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BY10-F1	alphafold	PREDICTED	80.58	—

Amino-acid sequence (475 residues)

MSPEVTCPRR GHLPRFHPRT WVEPVVASSQ VAASLYDAGL LLVVKASYGT GGSSNHSASP SPRGALEDQQ QRAISNFYII YNLVVGLSPL LSAYGLGWLS DRYHRKISIC MSLLGFLLSR LGLLLKVLLD WPVEVLYGAA ALNGLFGGFS AFWSGVMALG SLGSSEGRRS VRLILIDLML GLAGFCGSMA SGHLFKQMAG HSGQGLILTA CSVSCASFAL LYSLLVLKVP ESVAKPSQEL PAVDTVSGTV GTYRTLDPDQ LDQQYAVGHP PSPGKAKPHK TTIALLFVGA IIYDLAVVGT VDVIPLFVLR EPLGWNQVQV GYGMAAGYTI FITSFLGVLV FSRCFRDTTM IMIGMVSFGS GALLLAFVKE TYMFYIARAV MLFALIPVTT IRSAMSKLIK GSSYGKVFVI LQLSLALTGV VTSTLYNKIY QLTMDMFVGS CFALSSFLSF LAIIPISIVA YKQVPLSPYG DIIEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards