About Protein kinase C and casein kinase substrate in neurons protein 1
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) is a protein
from Homo sapiens identified by UniProt accession
Q9BY11, 444 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Protein kinase C and casein kinase substrate in neurons protein 1 |
|---|
| UniProt accession | Q9BY11 |
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| Gene | PACSIN1 |
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| Organism | Homo sapiens |
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| Length | 444 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- body mass index · score 0.38
- lean body mass · score 0.29
- physical activity measurement · score 0.29
- body weight · score 0.23
- eosinophil count · score 0.20
- fat body mass · score 0.19
- body weights and measures · score 0.12
- whole body water mass · score 0.10
- monocyte count · score 0.07
- hip circumference · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BY11-F1 | alphafold | PREDICTED | 84.20 | — |
Amino-acid sequence (444 residues)
MSSSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMNCVQERA KIEKAYGQQL TDWAKRWRQL IEKGPQYGSL ERAWGAIMTE ADKVSELHQE VKNNLLNEDL EKVKNWQKDA YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA MTREMNSKTE QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLEDVGKTT PQYMENMEQV FEQCQQFEEK RLVFLKEVLL DIKRHLNLAE NSSYIHVYRE LEQAIRGADA QEDLRWFRST SGPGMPMNWP QFEEWNPDLP HTTTKKEKQP KKAEGVALTN ATGAVESTSQ AGDRGSVSSY DRGQPYATEW SDDESGNPFG GSETNGGANP FEDDSKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE QGWCRGRLDS GQLGLYPANY VEAI
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