About S phase cyclin A-associated protein in the endoplasmic reticulum
S phase cyclin A-associated protein in the endoplasmic reticulum (SCAPER) is a protein
from Homo sapiens identified by UniProt accession
Q9BY12, 1400 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | S phase cyclin A-associated protein in the endoplasmic reticulum |
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| UniProt accession | Q9BY12 |
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| Gene | SCAPER |
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| Organism | Homo sapiens |
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| Length | 1400 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (166)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder and retinitis pigmentosa; IDDRP · score 0.69
- retinitis pigmentosa · score 0.45
- Cone rod dystrophy · score 0.43
- Intellectual disability, moderate · score 0.43
- genetic disorder · score 0.41
- Bardet-Biedl syndrome · score 0.37
- autosomal recessive non-syndromic intellectual disability · score 0.37
- Intellectual disability · score 0.34
- attention deficit hyperactivity disorder · score 0.34
- Pigmentary retinopathy · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BY12-F1 | alphafold | PREDICTED | 67.68 | — |
Amino-acid sequence (1400 residues)
MMASFQRSNS HDKVRRIVAE EGRTARNLIA WSVPLESKDD DGKPKCQTGG KSKRTIQGTH KTTKQSTAVD CKITSSTTGD KHFDKSPTKT RHPRKIDLRA RYWAFLFDNL RRAVDEIYVT CESDQSVVEC KEVLMMLDNY VRDFKALIDW IQLQEKLEKT DAQSRPTSLA WEVKKMSPGR HVIPSPSTDR INVTSNARRS LNFGGSTGTV PAPRLAPTGV SWADKVKAHH TGSTASSEIT PAQSCPPMTV QKASRKNERK DAEGWETVQR GRPIRSRSTA VMPKVSLATE ATRSKDDSDK ENVCLLPDES IQKGQFVGDG TSNTIESHPK DSLHSCDHPL AEKTQFTVST LDDVKNSGSI RDNYVRTSEI SAVHIDTECV SVMLQAGTPP LQVNEEKFPA EKARIENEMD PSDISNSMAE VLAKKEELAD RLEKANEEAI ASAIAEEEQL TREIEAEENN DINIETDNDS DFSASMGSGS VSFCGMSMDW NDVLADYEAR ESWRQNTSWG DIVEEEPARP PGHGIHMHEK LSSPSRKRTI AESKKKHEEK QMKAQQLREK LREEKTLKLQ KLLEREKDVR KWKEELLDQR RRMMEEKLLH AEFKREVQLQ AIVKKAQEEE AKVNEIAFIN TLEAQNKRHD VLSKLKEYEQ RLNELQEERQ RRQEEKQARD EAVQERKRAL EAERQARVEE LLMKRKEQEA RIEQQRQEKE KAREDAARER ARDREERLAA LTAAQQEAME ELQKKIQLKH DESIRRHMEQ IEQRKEKAAE LSSGRHANTD YAPKLTPYER KKQCSLCNVL ISSEVYLFSH VKGRKHQQAV RENTSIQGRE LSDEEVEHLS LKKYIIDIVV ESTAPAEALK DGEERQKNKK KAKKIKARMN FRAKEYESLM ETKNSGSDSP YKAKLQRLAK DLLKQVQVQD SGSWANNKVS ALDRTLGEIT RILEKENVAD QIAFQAAGGL TALEHILQAV VPATNVNTVL RIPPKSLCNA INVYNLTCNN CSENCSDVLF SNKITFLMDL LIHQLTVYVP DENNTILGRN TNKQVFEGLT TGLLKVSAVV LGCLIANRPD GNCQPATPKI PTQEMKNKPS QGDPFNNRVQ DLISYVVNMG LIDKLCACFL SVQGPVDENP KMAIFLQHAA GLLHAMCTLC FAVTGRSYSI FDNNRQDPTG LTAALQATDL AGVLHMLYCV LFHGTILDPS TASPKENYTQ NTIQVAIQSL RFFNSFAALH LPAFQSIVGA EGLSLAFRHM ASSLLGHCSQ VSCESLLHEV IVCVGYFTVN HPDNQVIVQS GRHPTVLQKL CQLPFQYFSD PRLIKVLFPS LIAACYNNHQ NKIILEQEMS CVLLATFIQD LAQTPGQAEN QPYQPKGKCL GSQDYLELAN RFPQQAWEEA RQFFLKKEKK
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