About Adhesion G protein-coupled receptor E3
Adhesion G protein-coupled receptor E3 (ADGRE3) is a protein
from Homo sapiens identified by UniProt accession
Q9BY15, 652 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Adhesion G protein-coupled receptor E3 |
|---|
| UniProt accession | Q9BY15 |
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| Gene | ADGRE3 |
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| Organism | Homo sapiens |
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| Length | 652 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.26
- bone density · score 0.26
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- platelet component distribution width · score 0.14
- low grade glioma · score 0.10
- body height · score 0.06
- Hiatus hernia · score 0.06
- metabolite measurement · score 0.04
- hepatocellular carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BY15-F1 | alphafold | PREDICTED | 80.53 | — |
Amino-acid sequence (652 residues)
MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT SGSGQKLFTF PLETCNDINE CTPPYSVYCG FNAVCYNVEG SFYCQCVPGY RLHSGNEQFS NSNENTCQDT TSSKTTEGRK ELQKIVDKFE SLLTNQTLWR TEGRQEISST ATTILRDVES KVLETALKDP EQKVLKIQND SVAIETQAIT DNCSEERKTF NLNVQMNSMD IRCSDIIQGD TQGPSAIAFI SYSSLGNIIN ATFFEEMDKK DQVYLNSQVV SAAIGPKRNV SLSKSVTLTF QHVKMTPSTK KVFCVYWKST GQGSQWSRDG CFLIHVNKSH TMCNCSHLSS FAVLMALTSQ EEDPVLTVIT YVGLSVSLLC LLLAALTFLL CKAIRNTSTS LHLQLSLCLF LAHLLFLVGI DRTEPKVLCS IIAGALHYLY LAAFTWMLLE GVHLFLTARN LTVVNYSSIN RLMKWIMFPV GYGVPAVTVA ISAASWPHLY GTADRCWLHL DQGFMWSFLG PVCAIFSANL VLFILVFWIL KRKLSSLNSE VSTIQNTRML AFKATAQLFI LGCTWCLGLL QVGPAAQVMA YLFTIINSLQ GFFIFLVYCL LSQQVQKQYQ KWFREIVKSK SESETYTLSS KMGPDSKPSE GDVFPGQVKR KY
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