About Membrane-spanning 4-domains subfamily A member 8
Membrane-spanning 4-domains subfamily A member 8 (MS4A8) is a protein
from Homo sapiens identified by UniProt accession
Q9BY19, 250 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 8 |
|---|
| UniProt accession | Q9BY19 |
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| Gene | MS4A8 |
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| Organism | Homo sapiens |
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| Length | 250 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (22)
Diseases linked to this target (Open Targets).
- alcohol drinking · score 0.09
- Barrett's esophagus · score 0.07
- esophageal adenocarcinoma · score 0.04
- lung carcinoma · score 0.03
- Crohn's disease · score 0.03
- platelet count · score 0.02
- colon carcinoma · score 0.02
- nasopharyngeal neoplasm · score 0.01
- gastric carcinoma · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BY19-F1 | alphafold | PREDICTED | 71.85 | — |
Amino-acid sequence (250 residues)
MNSMTSAVPV ANSVLVVAPH NGYPVTPGIM SHVPLYPNSQ PQVHLVPGNP PSLVSNVNGQ PVQKALKEGK TLGAIQIIIG LAHIGLGSIM ATVLVGEYLS ISFYGGFPFW GGLWFIISGS LSVAAENQPY SYCLLSGSLG LNIVSAICSA VGVILFITDL SIPHPYAYPD YYPYAWGVNP GMAISGVLLV FCLLEFGIAC ASSHFGCQLV CCQSSNVSVI YPNIYAANPV ITPEPVTSPP SYSSEIQANK
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