About Eukaryotic translation initiation factor 2A
Eukaryotic translation initiation factor 2A (EIF2A) is a protein
from Homo sapiens identified by UniProt accession
Q9BY44, 585 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 2A |
|---|
| UniProt accession | Q9BY44 |
|---|
| Gene | EIF2A |
|---|
| Organism | Homo sapiens |
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| Length | 585 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (95)
Diseases linked to this target (Open Targets).
- congenital hypothyroidism · score 0.15
- Marinesco-Sjögren syndrome · score 0.12
- acute myeloid leukemia · score 0.05
- PR interval · score 0.05
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
- colonic neoplasm · score 0.04
- platelet component distribution width · score 0.04
- neoplasm · score 0.04
- dominant beta-thalassemia · score 0.04
- hemoglobin D disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BY44-F1 | alphafold | PREDICTED | 85.53 | — |
Amino-acid sequence (585 residues)
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL FAWGNGEKVN IISVTNKGLL HSFDLLKAVC LEFSPKNTVL ATWQPYTTSK DGTAGIPNLQ LYDVKTGTCL KSFIQKKMQN WCPSWSEDET LCARNVNNEV HFFENNNFNT IANKLHLQKI NDFVLSPGPQ PYKVAVYVPG SKGAPSFVRL YQYPNFAGPH AALANKSFFK ADKVTMLWNK KATAVLVIAS TDVDKTGASY YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT IFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSILHKY DVPSNAELWQ VSWQPFLDGI FPAKTITYQA VPSEVPNEEP KVATAYRPPA LRNKPITNSK LHEEEPPQNM KPQSGNDKPL SKTALKNQRK HEAKKAAKQE ARSDKSPDLA PTPAPQSTPR NTVSQSISGD PEIDKKIKNL KKKLKAIEQL KEQAATGKQL EKNQLEKIQK ETALLQELED LELGI
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