Peroxisomal trans-2-enoyl-CoA reductase (PECR)

About Peroxisomal trans-2-enoyl-CoA reductase

Peroxisomal trans-2-enoyl-CoA reductase (PECR) is a protein from Homo sapiens identified by UniProt accession Q9BY49, 303 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Peroxisomal trans-2-enoyl-CoA reductase
UniProt accession	Q9BY49
Gene	PECR
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

metabolite measurement · score 0.24
alcohol dependence · score 0.18
protein measurement · score 0.08
age at menopause · score 0.07
heel bone mineral density · score 0.06
vital capacity · score 0.03
forced expiratory volume · score 0.03
body height · score 0.03
macula measurement · score 0.02
PHF-tau measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BY49-F1	alphafold	PREDICTED	94.29	—

Amino-acid sequence (303 residues)

MASWAKGRSY LAPGLLQGQV AIVTGGATGI GKAIVKELLE LGSNVVIASR KLERLKSAAD ELQANLPPTK QARVIPIQCN IRNEEEVNNL VKSTLDTFGK INFLVNNGGG QFLSPAEHIS SKGWHAVLET NLTGTFYMCK AVYSSWMKEH GGSIVNIIVP TKAGFPLAVH SGAARAGVYN LTKSLALEWA CSGIRINCVA PGVIYSQTAV ENYGSWGQSF FEGSFQKIPA KRIGVPEEVS SVVCFLLSPA ASFITGQSVD VDGGRSLYTH SYEVPDHDNW PKGAGDLSVV KKMKETFKEK AKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards